비스포스포네이트 관련 악골 골괴사: 문헌고찰
Bisphosphonate-related osteonecrosis of the jaws: A literature review
오지수, 김수관, 유재식, 김지원, 김은식, 임경섭, 김철만,
소속 상세정보
오지수 ( Oh Ji-Su ) - 조선대학교 치의학전문대학원 구강악안면외과학교실
김수관 ( Kim Su-Gwan ) - 조선대학교 치의학전문대학원 구강악안면외과학교실
유재식 ( You Jae-Seek ) - 조선대학교 치의학전문대학원 구강악안면외과학교실
김지원 ( Kim Ji-Won ) - 조선대학교 치의학전문대학원 구강악안면외과학교실
김은식 ( Kim Eun-Sik ) - 조선대학교 치의학전문대학원 구강악안면외과학교실
임경섭 ( Lim Kyung-Seop ) - 조선대학교 치의학전문대학원 구강악안면외과학교실
김철만 ( Kim Cheol-Man ) - 조선대학교 치의학전문대학원 구강악안면외과학교실
KMID : 0353320140380010001
Abstract
The aim of the present study was to review bisphosphonate osteonecrosis of the jaws (BRONJ). Bisphosphonate, pathophysiology, risk factors, staging, clinical manifestation, treatments, and prevention of BRONJ were investigated through a literature search. Bisphosphonates are a group of drugs that treat diseases related to bone resorption such as Paget`s disease, osteoporosis, and osseous metastases. BRONJ is defined as exposure and necrosis of bone in the oral cavity for at least 8 weeks in patients receiving bisphosphonate and with no history of radiotherapy of the jaws. Many articles have reported risk factors associated with BRONJ such as systemic diseases, oral infection, poor oral hygiene, and intraoral trauma. The objectives of BRONJ treatment are to minimize necrosis and relieve symptoms. Many treatments are suggested from conservative treatment to radical intervention, but this remains controversial. BRONJ remains a difficult condition to treat although many studies are being carried out.
키워드
Jaw; Necrosis; Oral surgery; Osteomyelitis
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